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Three essential thyroid markers — TSH, Free T4, Free T3 — to screen for over- or under-active thyroid function.
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A three-marker thyroid panel measuring TSH, Free T4, and Free T3 — the standard markers for assessing thyroid hormone production and conversion.
Your thyroid gland regulates metabolism, energy, mood, temperature, and weight. When it under- or over-produces hormones, the effects ripple across virtually every body system. The Essential Thyroid Check measures the three key markers that clinicians use to assess thyroid status: TSH (the pituitary signal that drives thyroid output), Free T4 (the main hormone the gland secretes), and Free T3 (the active form that cells actually use).
Together these three values give a clear picture of whether your thyroid axis is functioning normally, overactive, or underactive. The test is popular with people experiencing unexplained fatigue, difficulty losing weight, cold intolerance, hair thinning, brain fog, or mood changes — all common presentations of thyroid dysfunction.
Collect your sample at home with our fingerstick kit, book a mobile phlebotomist, or visit a partner clinic. Results are reviewed by a GMC-registered physician and returned to your secure online dashboard within 3 to 5 working days.
Understand what each marker measures, why it matters, and what the science says — not just a list of numbers.
Pituitary signal that drives thyroid hormone production; the primary screening marker for thyroid dysfunction.
Main hormone secreted by the thyroid gland; precursor converted to the active Free T3 in peripheral tissues.
The biologically active thyroid hormone that acts on cells to regulate energy, temperature, and metabolism.
This panel is designed for adults who want a comprehensive, evidence-based picture of their metabolic health — not a GP referral panel.
People experiencing unexplained fatigue or low energy
Those noticing unexpected weight gain or difficulty losing weight
Anyone with hair thinning, cold intolerance, or brain fog
Those monitoring thyroid health as part of a general wellness routine
This panel screens the central thyroid axis but does not measure thyroid antibodies (TPO or TG), which are essential for diagnosing autoimmune thyroid conditions such as Hashimoto's thyroiditis or Graves' disease. It does not include Reverse T3, which can be relevant in complex or chronic illness presentations. A normal TSH result does not exclude all forms of thyroid pathology; clinical symptoms should always be discussed with a qualified physician. This test is not intended to diagnose, treat, or manage any medical condition. If your results fall outside the reference range, a follow-up consultation with a GP or endocrinologist is recommended.
From order to physician-reviewed report in as little as three working days.
Three options designed to fit your schedule, location, and preference — all producing a laboratory-standard sample.
Adults 18+ in mainland UK. Not suitable if you have had a transfusion in the last 3 months.
Order anytime; kit dispatched within 24 hours Mon–Fri.
Allow 24–48 hours for sample transit on top of lab processing time.
Adults 18+ within 20 miles of a serviced city centre.
Mon–Sun, 06:00–20:00. Next-day booking typical.
Sample reaches the lab within 24 hours of collection.
Adults 16+ with photo ID. Paediatric draws by appointment at selected sites.
Mon–Fri, with Saturday hours at most metropolitan locations.
Samples processed same-day at the receiving clinic.
Every test is processed in a UKAS ISO 15189-accredited laboratory, overseen by GMC-registered physicians, and governed by UK GDPR. No overseas processing, no offshore data.
Follow these guidelines to ensure accurate, reproducible results. Most markers are sensitive to recent food, exercise, and sleep.
Can't find your answer? Our clinical support team is available Monday to Friday, 9am–5pm.
Contact supportTSH (thyroid-stimulating hormone) is produced by the pituitary gland in your brain, not the thyroid itself. It acts as a messenger signal: when the pituitary detects that thyroid hormone levels are low, it releases more TSH to prompt the thyroid to produce more. A high TSH therefore often indicates an underactive thyroid (hypothyroidism), while a low TSH can suggest an overactive thyroid (hyperthyroidism). TSH is the single most sensitive early marker for thyroid dysfunction and is always the first result clinicians examine.
T4 is the thyroid’s main output hormone, but it must be converted to the more active T3 in peripheral tissues such as the liver, gut, and muscles. Some individuals convert T4 to T3 poorly — a pattern that TSH and T4 alone would miss. By measuring Free T3 (the unbound, biologically active fraction), this panel helps identify situations where T4 is normal but T3 is low, which can explain persistent symptoms in people already on standard levothyroxine therapy.
Generally, you should take your sample before your morning levothyroxine dose to get a true baseline reading, rather than a post-dose peak. However, the appropriate timing depends on your specific medication, dose, and what your prescriber wants to assess. Always check with your GP or endocrinologist before altering your medication schedule. This test does not replace your NHS monitoring; it supplements it.
Yes. Biotin (vitamin B7), commonly taken for hair and nail health, is used in the laboratory assays for TSH, FT4, and FT3. High-dose biotin supplementation can interfere with results, producing falsely low TSH or falsely elevated T4 and T3 values. Please stop any biotin-containing supplements at least 48 hours before collecting your sample. Standard multivitamin doses are generally fine, but higher-dose standalone biotin supplements (5 mg or more) should definitely be paused.
The standard reference range for adults is approximately 0.4 to 4.0 mIU/L, though this varies slightly between laboratories and age groups. Trupoint Health’s UKAS-accredited laboratory uses age-adjusted reference intervals that are shown alongside your result. A result within range does not guarantee the absence of thyroid dysfunction; symptoms and clinical context matter. Your results are reviewed by a GMC-registered physician who considers all three values together rather than any single marker in isolation.
NHS GPs often screen with TSH alone, and only add FT4 if TSH is abnormal. This panel includes all three markers — TSH, FT4, and Free T3 — as a single assessment, giving you a more complete picture of your thyroid axis from one sample. It is a private test and does not replace NHS care, but many people find the added detail useful, particularly if they have ongoing symptoms despite a ‘normal’ NHS TSH result.
Results are typically available within 3 to 5 working days of your sample being received by the laboratory. You will receive an email notification as soon as your results are ready on your secure Trupoint Health dashboard, where you can view your values alongside reference ranges and physician commentary.
