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Five-marker thyroid panel combining full function testing with autoimmune antibody screening for Hashimoto's and Graves' disease.
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A five-marker thyroid panel measuring TSH, Free T4, Free T3, TPO antibodies, and TG antibodies.
Most thyroid problems in the UK are autoimmune in origin — the immune system mistakenly attacks the thyroid gland, causing it to become underactive (Hashimoto’s) or overactive (Graves’ disease). Standard TSH-only screening misses the antibody picture entirely. Thyroid Function Plus combines TSH, Free T4, and Free T3 with Thyroid Peroxidase Antibodies (TPO Ab) and Thyroglobulin Antibodies (TG Ab), providing a comprehensive first-line assessment of both function and autoimmunity.
TPO antibodies are elevated in approximately 95% of Hashimoto’s cases and are an early warning sign even when TSH remains within range. TG antibodies add further sensitivity, particularly in people with seronegative Hashimoto’s (TPO-negative but TG-positive). Together, these five markers give clinicians the information needed to distinguish simple hypothyroidism from autoimmune disease — a distinction that significantly affects long-term management.
Collect at home with our fingerstick kit, via a mobile phlebotomist, or at a partner clinic. Results reviewed by a GMC-registered physician and delivered within 3 to 5 working days.
Understand what each marker measures, why it matters, and what the science says — not just a list of numbers.
Pituitary signal that drives thyroid hormone production; the primary screening marker for thyroid dysfunction.
Main hormone secreted by the thyroid gland; precursor converted to the active Free T3 in peripheral tissues.
The biologically active thyroid hormone that acts on cells to regulate energy, temperature, and metabolism.
Immune proteins targeting the enzyme responsible for thyroid hormone synthesis; elevated in around 95% of Hashimoto's cases.
Immune proteins targeting the protein scaffold used in thyroid hormone production; adds sensitivity for autoimmune thyroid disease.
This panel is designed for adults who want a comprehensive, evidence-based picture of their metabolic health — not a GP referral panel.
People with hypothyroid symptoms whose TSH has come back 'normal'
Those with a family history of Hashimoto's thyroiditis or Graves' disease
Women experiencing fatigue, weight changes, or mood shifts around perimenopause
Anyone wanting to understand both thyroid function and immune status in one test
This panel covers the five markers most relevant for detecting autoimmune thyroid disease and assessing function but does not include Reverse T3, which can be relevant in complex presentations involving chronic illness or conversion problems. It does not measure nutritional co-factors such as ferritin, vitamin D, or selenium that influence thyroid function. Positive antibody results require clinical interpretation; many individuals with mildly elevated TPO antibodies have normal thyroid function for years and do not require immediate treatment. This test should not be used to start or stop any thyroid medication without appropriate medical consultation.
From order to physician-reviewed report in as little as three working days.
Three options designed to fit your schedule, location, and preference — all producing a laboratory-standard sample.
Adults 18+ in mainland UK. Not suitable if you have had a transfusion in the last 3 months.
Order anytime; kit dispatched within 24 hours Mon–Fri.
Allow 24–48 hours for sample transit on top of lab processing time.
Adults 18+ within 20 miles of a serviced city centre.
Mon–Sun, 06:00–20:00. Next-day booking typical.
Sample reaches the lab within 24 hours of collection.
Adults 16+ with photo ID. Paediatric draws by appointment at selected sites.
Mon–Fri, with Saturday hours at most metropolitan locations.
Samples processed same-day at the receiving clinic.
Every test is processed in a UKAS ISO 15189-accredited laboratory, overseen by GMC-registered physicians, and governed by UK GDPR. No overseas processing, no offshore data.
Follow these guidelines to ensure accurate, reproducible results. Most markers are sensitive to recent food, exercise, and sleep.
Can't find your answer? Our clinical support team is available Monday to Friday, 9am–5pm.
Contact supportTPO antibodies (thyroid peroxidase antibodies) are proteins produced by the immune system that mistakenly attack the enzyme TPO, which is essential for thyroid hormone synthesis. Elevated TPO antibodies are found in around 95% of people with Hashimoto’s thyroiditis and in a smaller proportion of those with Graves’ disease. Their presence indicates that the immune system is targeting the thyroid gland, which over time can impair its function. Detecting TPO antibodies early — even before TSH becomes abnormal — allows for closer monitoring and earlier intervention if hypothyroidism develops.
Both are autoimmune thyroid conditions, but they affect the gland in opposite ways. Hashimoto’s thyroiditis causes the immune system to slowly destroy thyroid tissue, leading to an underactive thyroid (hypothyroidism) over time. Graves’ disease produces antibodies that stimulate the thyroid to produce too much hormone, causing hyperthyroidism. Both conditions are associated with elevated TPO antibodies, though Graves’ disease also involves specific TSH receptor antibodies (TRAb) that are not included in this panel. This test is most useful for screening for Hashimoto’s; if Graves’ is suspected, a physician may request additional testing.
Yes, and it is relatively common. The thyroid gland has considerable reserve capacity, so the immune attack can be well underway before TSH shifts outside the reference range. This is sometimes called ‘euthyroid Hashimoto’s’ — the immune component is active but thyroid output remains adequate. In this situation, regular monitoring every 6 to 12 months is usually recommended so that any decline in function is caught early. Some research also links elevated TPO antibodies to increased pregnancy loss risk, making testing particularly relevant for women planning to conceive.
In most cases TPO antibodies alone are sufficient to detect Hashimoto’s, since TPO is positive in around 95% of cases. However, roughly 5% of people with autoimmune thyroid disease are TPO-negative but TG-positive — testing both together ensures this minority is not missed. TG antibodies are also used in the monitoring of thyroid cancer survivors, where rising TG Ab can indicate recurrence. Including both in a single panel maximises diagnostic sensitivity with one collection.
This test provides the data a clinician needs to make that assessment, but prescribing decisions must be made by a qualified physician based on your full clinical picture, including symptoms, TSH level, antibody status, and personal circumstances. Elevated antibodies alone are not an automatic indication for treatment. If your results suggest autoimmune thyroid disease, the report from Trupoint Health’s GMC-registered physician will include guidance on appropriate next steps and whether a follow-up consultation is advisable.
Antibody testing requires a small volume of serum, which can be obtained from a fingerstick capillary blood sample — the same type used for function tests. Your Trupoint Health kit includes a lancet, a collection tube, alcohol wipes, a plaster, and a prepaid return envelope. Warm your hands before collecting to ensure good blood flow. The laboratory processes the sample within 24 to 48 hours of receipt, and a physician reviews the results before they are released to your dashboard, typically within 3 to 5 working days.
If all results are within range, retesting annually as part of a broader health check is a reasonable approach for those with a family history of thyroid disease or mild symptoms. If you have confirmed elevated antibodies with normal function, six-monthly monitoring is commonly recommended so that any functional decline is detected promptly. Always follow the guidance provided in your Trupoint Health results report and discuss frequency with your GP or specialist if you are already under clinical care.
