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A 50-plus biomarker ultimate health check covering full hormones including cortisol and dehydroepiandrosterone sulphate (DHEA-S), advanced thyroid with antibodies, active B12, zinc, iron, vitamin D, folate, HbA1c, magnesium, and complete organ function — available as a home fingerstick kit or venous draw, processed at a UKAS ISO 15189-accredited laboratory, and reviewed by a GMC-registered physician within 3 to 5 working days.
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A 50-plus biomarker ultimate wellbeing panel covering full blood count, advanced thyroid with antibodies, full hormone panel (9 markers), liver, kidneys.
The Ultimate Wellbeing Health Check is Trupoint’s most comprehensive General Health panel — a 50-plus biomarker assessment spanning every key physiological system relevant to wellbeing, performance, and long-term health. It adds full hormone assessment — including SHBG, testosterone, oestradiol, LH, FSH, FAI, prolactin, cortisol, and dehydroepiandrosterone sulphate (DHEA-S) — to an already comprehensive base of thyroid, vitamins, minerals, organ function, and cardiovascular markers.
The inclusion of active B12 (holotranscobalamin) alongside total B12 is clinically significant: up to 30 per cent of people with normal total B12 have low active B12, meaning functional deficiency is missed by a standard B12 test. Zinc is included as an often-overlooked mineral essential for immune function, testosterone production, and wound healing.
This is the broadest available General Health panel without requiring a specialist prescription, making it ideal for adults who want the most complete annual picture of their health across hormones, thyroid, nutrition, metabolic, and organ function simultaneously.
Understand what each marker measures, why it matters, and what the science says — not just a list of numbers.
Nine sex hormones and adrenal markers providing a complete picture of reproductive status, adrenal function, and androgenic balance in both men and women.
The primary oestrogen. In premenopausal women, reflects follicular activity and ovarian health. In men, elevated oestradiol (often from aromatisation) can suppress testosterone and cause symptoms.
Pituitary hormones controlling gonadal function. In women, elevated FSH and LH indicate declining ovarian reserve or menopause. In men, low values suggest pituitary-level testosterone suppression.
SHBG binds testosterone, making a proportion unavailable to tissues. The FAI (free androgen index) calculates the bioavailable fraction and is more clinically useful than total testosterone alone.
Elevated prolactin can suppress both testosterone and oestradiol, causing reduced libido, infertility, and menstrual irregularity. Stress, medications, and pituitary adenoma are common causes.
The primary stress hormone produced by the adrenal glands. Chronic elevation is associated with immune suppression, blood sugar dysregulation, and testosterone suppression in both sexes.
An adrenal androgen that declines progressively with age. Low dehydroepiandrosterone sulphate (DHEA-S) is associated with fatigue, low mood, reduced libido, and poor stress resilience — a key marker of adrenal function and hormonal ageing.
A complete thyroid screen including TPO and TG antibodies — identifying autoimmune thyroid disease at the earliest stage, often years before TSH becomes abnormal.
The three-marker thyroid screen. TSH indicates overall pituitary-thyroid communication; FT4 and FT3 assess secretion and peripheral conversion of the active thyroid hormone.
Autoimmune thyroid markers. Positive antibodies indicate Hashimoto's or Graves' activity and often precede thyroid dysfunction by years. Identifying them early allows proactive monitoring.
Six micronutrient markers including active B12 and zinc — providing a more complete picture of nutritional status than a basic vitamin panel.
Active B12 (holotranscobalamin) measures only the fraction delivered to cells. Up to 30 per cent of people with normal total B12 have low active B12, making this a more sensitive marker of functional deficiency.
Complete nutritional panel covering folate (B9), vitamin D status, and the three-marker iron screen — the most commonly deficient nutrients in UK adults.
Essential for immune function, testosterone biosynthesis, wound healing, and skin health. Deficiency is underdiagnosed and associated with immune dysfunction, reduced fertility, and poor wound repair.
Involved in over 300 enzymatic processes including testosterone synthesis, energy production, and glucose metabolism. Deficiency causes muscle cramps, fatigue, and poor sleep quality.
Complete liver function, kidney function, cholesterol, HbA1c, and CRP provide the essential metabolic and organ function foundation of this flagship wellbeing assessment.
Comprehensive cell count screening all three blood cell lines — providing broad immune, anaemia, and bone marrow health data.
Complete organ function panel. The full liver enzyme and protein panel, kidney filtering markers with uric acid, and the six-marker lipid profile including non-HDL and ratio.
Blood sugar regulation over three months and systemic inflammation — the two most impactful preventative biomarkers for metabolic and cardiovascular health risk stratification.
This panel is designed for adults who want a comprehensive, evidence-based picture of their metabolic health — not a GP referral panel.
Adults who want the most thorough available general health check — covering hormones, thyroid, advanced vitamins, organ function, and cardiovascular markers — in one annual panel.
Those with a combination of fatigue, mood changes, libido changes, weight shifts, and poor sleep who want a broad hormonal and nutritional screen before committing to a specialist panel.
Health-conscious adults and athletes who want objective data on their hormonal, nutritional, and metabolic status to inform supplementation, training, and lifestyle decisions.
Men and women in their 40s and 50s wanting a thorough assessment of hormonal change alongside the full spectrum of cardiovascular, metabolic, and nutritional markers.
Adults discussing hormone replacement with their GP or specialist who want a comprehensive pre-treatment baseline across all hormone, thyroid, metabolic, and organ function markers.
This panel is a screening and baselining tool, not a clinical diagnosis. Hormone results in premenopausal women are highly cycle-dependent — FSH, LH, oestradiol, and progesterone can only be meaningfully interpreted when collected at the correct cycle phase. Cortisol and testosterone follow strong morning-to-evening decline and must be collected before 10am for accurate results. Thyroid antibody positivity does not confirm active thyroid disease. Active B12 does not account for intracellular B12 and may be normal in some deficiency states. The panel does not screen for cancer, pelvic pathology, structural cardiac disease, or infectious disease. All out-of-range results should be reviewed with a clinician who has access to your full medical history.
From order to physician-reviewed report in as little as three working days.
Dispatched next working day by Royal Mail Tracked 24 in discreet plain packaging.
Please fast for 10 to 12 hours and follow the collection instructions provided.
Your sample is barcoded, logged, and processed at a UKAS ISO 15189-accredited laboratory.
A GMC-registered physician reviews all results and provides clinical commentary before releasing your report.
Three options designed to fit your schedule, location, and preference — all producing a laboratory-standard sample.
Adults 18+ in mainland UK. Not suitable if you have had a transfusion in the last 3 months.
Order anytime; kit dispatched within 24 hours Mon–Fri.
Allow 24–48 hours for sample transit on top of lab processing time.
Adults 18+ within 20 miles of a serviced city centre.
Mon–Sun, 06:00–20:00. Next-day booking typical.
Sample reaches the lab within 24 hours of collection.
Adults 16+ with photo ID. Paediatric draws by appointment at selected sites.
Mon–Fri, with Saturday hours at most metropolitan locations.
Samples processed same-day at the receiving clinic.
Every test is processed in a UKAS ISO 15189-accredited laboratory, overseen by GMC-registered physicians, and governed by UK GDPR. No overseas processing, no offshore data.
Follow these guidelines to ensure accurate, reproducible results. Most markers are sensitive to recent food, exercise, and sleep.
Can't find your answer? Our clinical support team is available Monday to Friday, 9am–5pm.
Contact supportTotal vitamin B12 measures all forms of B12 in the blood, including forms bound to haptocorrin — a carrier protein that delivers B12 to the liver but not to peripheral tissues. Only holotranscobalamin (active B12) is taken up by cells throughout the body and is therefore the metabolically relevant fraction. Studies show that 25 to 30 per cent of people with total B12 in the normal range have low active B12, meaning they have genuine functional deficiency despite a reassuring standard test. Active B12 is a more sensitive early marker of deficiency and is particularly important in older adults, vegans, those on metformin, and people taking proton pump inhibitors.
dehydroepiandrosterone sulphate (DHEA-S) (dehydroepiandrosterone sulphate) is an adrenal androgen precursor that the body converts to sex hormones including testosterone and oestradiol. dehydroepiandrosterone sulphate (DHEA-S) peaks in the mid-20s and then declines progressively — levels in an average 70-year-old are roughly 80 per cent lower than in a 25-year-old. This decline is associated with fatigue, reduced stress resilience, low libido, and poor immune function. Low dehydroepiandrosterone sulphate (DHEA-S) in a younger adult may indicate adrenal insufficiency or chronic stress. Testing dehydroepiandrosterone sulphate (DHEA-S) alongside cortisol gives a picture of adrenal hormone balance: high cortisol with low dehydroepiandrosterone sulphate (DHEA-S) is a pattern sometimes called adrenal dysregulation and is associated with poor recovery from physical and psychological stress.
A mildly elevated prolactin on a single test is very common and frequently caused by the stress of the blood draw itself (known as stress-induced hyperprolactinaemia), rather than a genuine pathological elevation. Other common non-pathological causes include vigorous exercise before the test, certain medications (including antipsychotics, antidepressants, and antiemetics), nipple stimulation, and eating a large meal shortly beforehand. A single mildly elevated prolactin result should always be repeated — ideally in a relaxed morning fasted state with a minimum 30 minutes of rest before collection. Persistently elevated prolactin on repeat testing warrants GP assessment to exclude a pituitary adenoma (prolactinoma).
Yes. This panel includes serum zinc, which reflects extracellular zinc status and is the most practical clinical marker of zinc deficiency. It is most reliable when collected in a fasted state, as zinc levels fall after meals. Serum zinc does not fully capture intracellular zinc stores — a normal result does not definitively rule out subclinical deficiency, particularly in people with high zinc requirements such as athletes, those with inflammatory bowel disease, or those with high alcohol intake. Low serum zinc is clinically significant and warrants supplementation or dietary review. The physician’s commentary will interpret your result in the context of your other markers and reported symptoms.
Yes. Testosterone, cortisol, and dehydroepiandrosterone sulphate (DHEA-S) all follow a marked circadian rhythm, with peak levels occurring in the morning. Testosterone in men is typically 20 to 30 per cent higher before 10am than in the afternoon; cortisol follows a similar pattern. For the most clinically accurate and comparable results, morning collection before 10am is strongly recommended. FSH, LH, and oestradiol in premenopausal women are better collected on days 2 to 5 of the menstrual cycle. If morning collection is not possible for practical reasons, the physician’s commentary will note the collection timing and adjust interpretation accordingly.
Blood tests provide objective data on biomarker levels but cannot replace physical examination, blood pressure assessment, body composition measurement, or imaging. This panel covers the most informative blood-based markers available in a single draw, giving you a comprehensive picture of your biochemical health. For a complete health picture — including blood pressure, heart rhythm assessment, or abdominal palpation — a GP or private health check consultation is recommended alongside your blood results. Your Trupoint report will clearly highlight any findings that suggest a physical examination or further investigation is warranted.
