Comprehensive Thyroid Health Panel

Ferritin is the body’s iron storage protein. Iron is required at several points in thyroid hormone synthesis — including the function of the enzyme thyroid peroxidase, which is responsible for producing T4. Additionally, iron is needed for the conversion of T4 to the active T3 in peripheral tissues. When ferritin is low (even within the technically ‘normal’ lab range), thyroid hormone production and conversion can be impaired, leading to hypothyroid-like symptoms even when TSH appears normal. Many people with Hashimoto’s have suboptimal ferritin that, when optimised, significantly improves their wellbeing.

Multiple studies have shown a significant association between vitamin D deficiency and elevated thyroid antibodies, particularly TPO antibodies. Vitamin D plays an important role in immune regulation and modulating autoimmune responses. Several clinical trials have found that correcting vitamin D deficiency reduces TPO antibody levels in people with Hashimoto’s thyroiditis, though the evidence is not yet strong enough to establish a definitive therapeutic recommendation. Measuring vitamin D alongside your antibodies allows you to identify and address this co-factor under medical guidance.

Yes, this panel is particularly relevant for people already taking levothyroxine who continue to experience symptoms such as fatigue, brain fog, weight gain, or mood changes despite a ‘normal’ TSH. Common reasons for persistent symptoms include: suboptimal T3 conversion (which this panel reveals via FT3), low ferritin impairing conversion, vitamin D or B12 deficiency mimicking hypothyroid symptoms, or ongoing autoimmune activity. The nutritional co-factor data in this panel can identify correctable causes of treatment-resistant symptoms.

Total B12 measures all forms of cobalamin in the blood, but not all of it is biologically available. Active B12 — also called holotranscobalamin — measures only the fraction that cells can actually take up and use. Total B12 can appear normal even when functional B12 status is poor, leading to deficiency symptoms being missed. Active B12 is a more sensitive early marker of deficiency and is especially relevant for older adults, vegans, and those taking proton pump inhibitors (PPIs). Since B12 deficiency symptoms closely overlap with hypothyroid symptoms, distinguishing the two is clinically important.

CRP is measured using a high-sensitivity assay in this panel. Values below 1 mg/L indicate low cardiovascular and inflammatory risk. Values between 1 and 3 mg/L suggest moderate risk and warrant lifestyle review. Values above 3 mg/L indicate elevated systemic inflammation that warrants further investigation to identify the source. Elevated CRP in the context of thyroid disease may reflect active autoimmune thyroid inflammation, but other causes — including infection, metabolic syndrome, or other autoimmune conditions — must also be considered. Your physician review will contextualise your CRP result.

For those with confirmed Hashimoto’s thyroiditis, monitoring every 6 to 12 months is a reasonable approach, depending on symptom stability and whether any interventions (nutritional, pharmaceutical, or lifestyle) are being trialled. If you are correcting a specific deficiency (e.g. ferritin or vitamin D), retesting 3 months after starting supplementation gives a useful indication of response. Always follow the guidance in your results report and coordinate your monitoring frequency with your GP or endocrinologist.

No. This panel provides rich data that supports clinical decision-making but does not replace the assessment of a qualified endocrinologist for complex or treatment-resistant thyroid conditions. If your results indicate significantly abnormal thyroid function, markedly elevated antibodies, or nutritional deficiencies requiring therapeutic intervention, our physician report will recommend appropriate next steps, which may include a GP consultation or specialist referral.