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Six-marker male hormone panel covering total and free testosterone, SHBG, LH, FSH, and oestradiol for a complete hormonal picture.
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A six-marker male hormone panel measuring total testosterone, free testosterone, SHBG, LH, FSH, and oestradiol.
Testosterone is the defining male hormone — it drives energy, libido, muscle mass, mood, bone density, and fertility. But testosterone does not act in isolation. SHBG (sex hormone-binding globulin) determines how much testosterone is free and biologically active. LH and FSH are the pituitary signals that govern testosterone production and sperm generation. And oestradiol — yes, men produce it too — plays a crucial role in bone health, cardiovascular function, and sexual wellbeing.
The Male Hormone Profile provides all six markers in a single panel, giving a complete view of the hypothalamic-pituitary-testicular axis. It is suitable for men experiencing low energy, reduced libido, difficulty building muscle, mood changes, or fertility concerns.
Venous blood draw required for accurate testosterone and oestradiol measurement. Book a mobile phlebotomist or partner clinic appointment. GMC-physician reviewed results within 3 to 5 working days.
Understand what each marker measures, why it matters, and what the science says — not just a list of numbers.
Total circulating testosterone including both bound and free fractions; primary androgen for energy, libido, muscle mass, and mood.
Biologically active testosterone not bound to SHBG or albumin; the fraction that acts on tissues and drives androgenic effects.
Carrier protein that binds testosterone; high SHBG lowers free testosterone and can cause symptoms of deficiency despite normal total levels.
Pituitary hormone that stimulates Leydig cells in the testes to produce testosterone; distinguishes primary from secondary hypogonadism.
Pituitary hormone that supports sperm production in the testes; elevated FSH suggests testicular impairment.
Oestrogen produced from testosterone via aromatase; essential for bone density, cardiovascular health, and sexual function in men.
This panel is designed for adults who want a comprehensive, evidence-based picture of their metabolic health — not a GP referral panel.
Men experiencing low energy, reduced libido, or mood changes
Those finding it difficult to build or maintain muscle mass
Men investigating possible testosterone deficiency or hypogonadism
Those concerned about fertility or sperm production
Testosterone levels fluctuate significantly throughout the day, peaking in the early morning. For accurate results, testing should be completed before 10 am. A single measurement does not capture daily or seasonal variation; results should be interpreted alongside symptoms and, where relevant, repeated to confirm. This panel does not include dehydroepiandrosterone sulphate (DHEA-S), prolactin, cortisol, or thyroid markers, which may be relevant for a complete picture of hormonal and adrenal health. Free testosterone is calculated from total testosterone and SHBG rather than directly measured, which is the standard clinical approach but introduces a small estimation error. Results should be interpreted by a physician familiar with male endocrinology.
From order to physician-reviewed report in as little as three working days.
Three options designed to fit your schedule, location, and preference — all producing a laboratory-standard sample.
Adults 18+ in mainland UK. Not suitable if you have had a transfusion in the last 3 months.
Order anytime; kit dispatched within 24 hours Mon–Fri.
Allow 24–48 hours for sample transit on top of lab processing time.
Adults 18+ within 20 miles of a serviced city centre.
Mon–Sun, 06:00–20:00. Next-day booking typical.
Sample reaches the lab within 24 hours of collection.
Adults 16+ with photo ID. Paediatric draws by appointment at selected sites.
Mon–Fri, with Saturday hours at most metropolitan locations.
Samples processed same-day at the receiving clinic.
Every test is processed in a UKAS ISO 15189-accredited laboratory, overseen by GMC-registered physicians, and governed by UK GDPR. No overseas processing, no offshore data.
Follow these guidelines to ensure accurate, reproducible results. Most markers are sensitive to recent food, exercise, and sleep.
Can't find your answer? Our clinical support team is available Monday to Friday, 9am–5pm.
Contact supportTotal testosterone measures all testosterone in the bloodstream, but most of it (around 97 to 99%) is bound to proteins — primarily SHBG (strongly bound) and albumin (loosely bound). Only the remaining fraction, called free testosterone, is biologically available to act on tissues. A man can have normal total testosterone but low free testosterone if SHBG is elevated — a common scenario in older men, men with obesity, liver disease, or those taking certain medications. Measuring SHBG alongside total testosterone allows free testosterone to be accurately calculated.
The normal range varies by laboratory and age. In adult men, total testosterone typically falls between 8 and 30 nmol/L, with values declining by approximately 1 to 2% per year after age 30. Symptoms of deficiency (fatigue, low libido, mood changes, reduced muscle mass) commonly occur when levels fall below 12 nmol/L, though some men experience symptoms at levels above this if SHBG is high and free testosterone is correspondingly low. Your Trupoint Health report will show age-adjusted reference ranges and physician commentary contextualising your result.
Men produce small amounts of oestradiol through the conversion of testosterone by an enzyme called aromatase, found primarily in fat tissue. Oestradiol in men is essential for bone health, cardiovascular protection, regulation of libido, and healthy sperm production. When oestradiol is too low — often in men on testosterone replacement therapy (TRT) without monitoring — it can cause joint pain, osteoporosis risk, and mood problems. When it is too high (common in men with obesity or high body fat), it can cause breast tissue growth (gynaecomastia), water retention, and suppression of natural testosterone production.
LH and FSH are produced by the pituitary gland to stimulate the testes. When the testes are not functioning adequately (primary hypogonadism — for example due to testicular injury, Klinefelter syndrome, or chemotherapy damage), the pituitary compensates by producing more LH and FSH. Elevated LH with low testosterone therefore points to a problem at the testicular level. By contrast, if both LH and testosterone are low, the problem is likely in the pituitary or hypothalamus (secondary hypogonadism). This distinction has significant implications for treatment and fertility prospects.
Acute intense exercise can temporarily raise testosterone levels in the hours immediately following a training session, which may not reflect your baseline. For this reason, we recommend avoiding intense exercise on the morning of your blood draw. Long-term endurance training (e.g. marathon training) is associated with chronically suppressed testosterone in some athletes — a pattern that would show on this panel. Resistance training over time generally supports healthy testosterone levels. Rest, quality sleep, and adequate caloric intake are important determinants of testosterone that lifestyle questions cannot capture but that are worth reviewing alongside your results.
Yes, regular monitoring is recommended for men on TRT. This panel provides the key safety and efficacy markers: total testosterone (to confirm levels are in the therapeutic range), free testosterone (to check bioavailability), oestradiol (to detect excess aromatisation), LH (which will be suppressed by exogenous testosterone — expected), and FSH (to assess fertility implications of TRT). Routine monitoring is essential for safe TRT management. Testing should be timed to your injection or gel cycle as instructed by your prescribing physician to obtain a consistent, comparable reading.
Your physician report will specify recommended next steps. In general, a GP referral is advisable if: total testosterone is below 8 nmol/L with symptoms; LH and FSH are both elevated (suggesting primary testicular failure); oestradiol is significantly elevated; or if results are normal but symptoms are severe and unexplained. A GP can arrange NHS repeat testing and, if appropriate, referral to an endocrinologist or andrologist for specialist assessment.
