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Biological monitoring of liver and kidney function for workers with occupational chemical exposure. Formatted for occupational health surveillance programmes.
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Targeted biological monitoring for workers with potential occupational exposure to hepatotoxic or nephrotoxic substances.
Workers in certain industries — manufacturing, construction, agriculture, laboratory science, and printing among others — may have regular occupational exposure to substances capable of causing liver or kidney damage. Biological monitoring of organ function allows employers to detect subclinical effects of exposure before clinically significant disease develops. This panel provides a comprehensive liver function assessment (ALT, AST, ALP, GGT, bilirubin, albumin, prothrombin time) alongside kidney function markers (creatinine, eGFR, urea, urine protein) and a full blood count. It is designed to be repeated at regular intervals as part of an occupational health surveillance programme. Results are accompanied by a GMC-registered physician report formatted for occupational health purposes, with reference to occupational medicine interpretation guidance. All samples are processed at a UKAS ISO 15189-accredited laboratory.
Understand what each marker measures, why it matters, and what the science says — not just a list of numbers.
This panel is designed for adults who want a comprehensive, evidence-based picture of their metabolic health — not a GP referral panel.
Workers in chemical manufacturing, printing, or laboratory settings with solvent exposure
Agricultural workers with pesticide or herbicide exposure
Healthcare workers handling hepatotoxic or nephrotoxic medications (chemotherapy staff)
Construction workers with potential heavy metal exposure (lead, cadmium, chromium)
Employers implementing a biological monitoring programme under COSHH regulations
This panel provides non-specific biological monitoring of hepatic and renal function and cannot attribute abnormalities to specific occupational exposures without the use of substance-specific biological exposure indices (BEIs). GGT is elevated by alcohol consumption independently of occupational exposure, which must be considered in interpretation. ALT and AST can also be elevated by non-alcoholic fatty liver disease, which is common in the general working population. Prothrombin time requires venous blood and cannot be reliably measured from a dried blood spot. Urine protein is measured by dipstick; a positive result should be confirmed by quantitative urine protein-to-creatinine ratio. This panel is intended as a serial surveillance tool; single measurements are less informative than longitudinal trends compared against an individual baseline.
From order to physician-reviewed report in as little as three working days.
Venous draw and mid-stream urine sample required.
To prevent alcohol-related GGT elevation confounding occupational results.
Within 24 hours of receipt.
GMC physician report in 3 to 5 working days.
Three options designed to fit your schedule, location, and preference — all producing a laboratory-standard sample.
Adults 18+ in mainland UK. Not suitable if you have had a transfusion in the last 3 months.
Order anytime; kit dispatched within 24 hours Mon–Fri.
Allow 24–48 hours for sample transit on top of lab processing time.
Adults 18+ within 20 miles of a serviced city centre.
Mon–Sun, 06:00–20:00. Next-day booking typical.
Sample reaches the lab within 24 hours of collection.
Adults 16+ with photo ID. Paediatric draws by appointment at selected sites.
Mon–Fri, with Saturday hours at most metropolitan locations.
Samples processed same-day at the receiving clinic.
Every test is processed in a UKAS ISO 15189-accredited laboratory, overseen by GMC-registered physicians, and governed by UK GDPR. No overseas processing, no offshore data.
Follow these guidelines to ensure accurate, reproducible results. Most markers are sensitive to recent food, exercise, and sleep.
Can't find your answer? Our clinical support team is available Monday to Friday, 9am–5pm.
Contact supportThe liver is the primary site of metabolism for many industrial chemicals, making it the organ most commonly affected by occupational chemical exposure. Organic solvents — including toluene, xylene, styrene, and chlorinated solvents such as trichloroethylene and carbon tetrachloride — are hepatotoxic at high exposure levels and can cause elevated GGT and ALT. Pesticides and herbicides, particularly organochlorine compounds, are also hepatotoxic. Certain metals, including arsenic and industrial iron dust, can cause liver injury. GGT is often the most sensitive marker of early solvent-related hepatic stress, rising before ALT in many cases.
The frequency of biological monitoring depends on the level and nature of the exposure. Under COSHH (Control of Substances Hazardous to Health) regulations, employers are required to implement health surveillance for workers with ongoing exposure to known hazardous substances. For most occupational settings with moderate exposures, annual monitoring is standard. Workers with higher exposures or those who show early changes on previous monitoring may require six-monthly testing. Baseline testing before starting in a new exposure role allows subsequent results to be compared against the individual’s own pre-exposure values, which is more sensitive than comparing to population reference ranges.
No. This panel tests for non-specific markers of organ function that may be affected by heavy metal exposure, but it does not directly measure blood lead, urinary cadmium, urinary mercury, or other specific metal exposure biomarkers. For substance-specific biological monitoring as required under COSHH for lead workers (Control of Lead at Work Regulations), blood lead measurement is required separately. Similarly, urine cadmium and urine beta-2-microglobulin are the specific markers used for cadmium exposure monitoring. Trupoint Health can provide guidance on specialist occupational toxicology testing if required.
Isolated GGT elevation — GGT above the reference range with normal ALT, AST, ALP, and bilirubin — is most commonly caused by alcohol consumption, even at levels not typically considered problematic. Certain medications (anticonvulsants, statins, rifampicin) also cause isolated GGT elevation. In an occupational context, isolated GGT elevation in a worker exposed to aromatic solvents may represent early enzyme induction from solvent metabolism, even without frank hepatocellular damage. It is a useful early warning sign but should be interpreted alongside the worker’s alcohol history and medication list before attributing it to occupational exposure.
